The Cameron Lab in the Department of Ophthalmic Research at the Cleveland Clinic Cole Eye Institute is seeking a highly motivated, creative, and independent scientist to study the cellular and molecular mechanisms that govern reactive astrocyte functions in the eye and optic nerve.
This fully-funded position includes the opportunity to utilize state-of-the-art multiomics approaches, rodent injury models, and human tissues to develop novel astrocyte-targeted gene therapies for glaucoma and other retinal diseases.
Candidates with a recent/expected Ph.D. should have a strong interest, background, and technical skills in several of the following: retinal and/or neurological disease, cellular and molecular biology, multiomics approaches (e.g., scRNAseq, mass spec), fluorescent microscopy, transcriptional regulation, intracellular signaling, and primary mammalian cell culture. Experience with AAV technologies and in vivo retinal disease/injury modeling is highly desired. The successful candidate will have the following responsibilities: Utilize high-throughput genomic and proteomic techniques (e.g., RNA sequencing, single-cell sequencing, spatial transcriptomics, mass spec) to identify critical genes and pathways involved in reactive astrocyte functions in the retina and optic nerve. Employ rodent ocular disease models, imaging, and behavioral assays to study the molecular, transcriptional, and functional consequences of cyclic-nucleotide signaling in reactive retinal and optic nerve astrocytes. Fluorescent and confocal microscopy of gene therapy effects in injured and diseased mouse ocular tissues. Preparation and maintenance of mouse and human primary cell cultures; purifying, characterizing and cryopreserving cells, in vitro pharmacological, expression, localization, proliferation, phosphoryaltion, and protein-protein interaction experiments.
Collaborating with team members to interpret data, generate hypotheses, and design follow-up experiments. Contributing to publishing research findings in peer-reviewed journals and presenting results at conferences and seminars.
Principal Investigator: Evan G. Cameron, PhD
Lerner Research Institute Department: Ophthalmic Research
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Keywords: Postdoc, Research, LRI, Retinal Disease, Gene Therapy, Reactive Astrocytes, Glaucoma, Retinal Ganglion Cells, Optic Nerve, Animal Disease Modeling, Cole Eye Institute, Cleveland Clinic Lerner Research Institute, Translational Neuroscience, Postdoc, Cleveland Clinic, Multiomics, Mass spec, RNAseq, Behavior, Pharmacology
Pay Range
Minimum hourly: $0.01
Maximum hourly: $333,340.26
The pay range displayed on this job posting reflects the anticipated range for new hires. While the pay range is displayed as an hourly rate, Cleveland Clinic recruiters will clarify whether the compensation is hourly or salary. A successful candidate's actual compensation will be determined after taking factors into consideration such as the candidate's work history, experience, skill set, and education. This is not inclusive of the value of Cleveland Clinic's benefits package, which includes among other benefits, healthcare/dental/vision and retirement.