Postdoctoral Associate- Pharmacokinetics

Summary

The Center for Drug Discovery ( https://www.bcm.edu/research/centers/drug-discovery ) is a strategic research center at Baylor College of Medicine in Houston, Texas. We are currently seeking highly motivated, well-organized and enthusiastic Postdoctoral Fellows contributing to our research in the fields of drug metabolism and toxicity, as well as the study of chemical properties that aid in crossing the blood-testis barrier (BTB). In our well-equipped laboratory, we utilize advanced instruments such as Thermos UHPLC-Q Exactive MS, Orbitrap Exploris™ 120, Thermo Quintus (triple quadruple), and Imaging mass spectrometry (IMS, Bruker timsTOF fleX MALDI-2) to conduct LC-MS-metabolomics, pharmacokinetics, and spatial metabolomics. Understanding the drug metabolism could predict the possible adverse events of drugs in clinic and also could reduce the risk of the drug candidates in drug development. Determining chemical features passing BTB will facilitate the drug development for therapeutic targets behind BTB. Baylor College of Medicine is located in the prestigious Texas Medical Center and offers a highly interactive environment and a strong infrastructure for research and career development. To obtain further details about the positions, feel free to email Dr. Feng Li ( [email protected] ) directly.

Job Duties

• Plans, designs and conducts experiments.
• Characterizes the drug metabolites using High-resolution LC-MS and NMR.
• Analyzes LC-MS data from mouse tissue and plasma to evaluate their abilities for passing through BTB.
• Documents and interprets experimental results and report to principal investigators.
• Conducts literature searches and summarizes information in an appropriate format for a particular study.
• Helps to write and prepare manuscripts.
• Performs other job related duties as assigned.

Minimum Qualifications

• MD or Ph.D. in Basic Science, Health Science, or a related field.
• No experience required.

Preferred Qualifications

• Doctoral degree in Chemistry, Drug metabolism and pharmacokinetics, Pharmacology, and Toxicology, or a related Biomedical Science discipline.
• Experience in medicinal chemistry and structural characterization using LC-MS and NMR.
• Skilled in the identification of drug metabolites in vitro and in vivo.
• Experience in working with animals, including animal treatment and tissue collection.
• Have the ability to plan, design and conduct experiments, especially on drug metabolism, tissue distribution, and metabolites identification. Pharmacology and toxicology backgrounds is a plus.
• Have the experience of preparing and writing the manuscript.
• Have experience in LC-MS method development and sample preparation, and data analysis